The classic mechanisms of tumor immune evasion include down-regulation of MHC expression, which leads to escape from CD8+ T cells [36], internalization of opsonizing Abs, recruitment of regulatory T cells and MDSCs, as well as the creation of an immune suppressive tumor microenvironment by secretion of anti-inflammatory cytokines in general [37]–[39]. This evidence concerns the gene HLA-C and neoplasm.