CD40LG and B-cell chronic lymphocytic leukemia: The purpose of our study was threefold, first we tested line differences in levels and binding profiles of total plasma antibodies (IgTotal) and the isotypes IgM and IgG to the auto-antigen CLL, second we correlated the staining patterns of IgM and IgG antibodies, and third we clustered binding profiles of the antibody isotypes: IgTotal, IgM and IgG per line using principal component analysis.