We have shown UPR-related mRNA loading onto glioma xenograft-derived tumor polyribosomes where GRP94, BiP/GRP78 and GAPDH mRNA distributions in the gradient fractions clearly demonstrate the efficient recruitment of UPR-sensitive transcripts into the heavy-sedimenting polyribosome fractions (Supplemental Figure S5). The gene discussed is HSP90B1; the disease is central nervous system cancer.