HSP90B1 and central nervous system cancer: In our analysis of this data set, we identified a 1.4- to 1.9- fold elevation (p<0.001) of BiP/GRP78, GRP94, and XBP-1 message levels in gliomas of the poorer prognostic subtypes (mesenchymal and proliferative) relative to the pronerual group (Table 3).