As noted in the names of the Top Networks, the relationships between cell proliferation and cell death via tumor cell manipulation of the UPR are evident here; in particular, the connections of these UPR-induced gene expressions and such important tumor signaling pathways as the PI3K/ERK, MAPK/AKT, VEGF/PDGF systems stand out (Figure 5D). This evidence concerns the gene VEGFA and neoplasm.