We recently proposed a pair of tandem polymorphic dinucleotides (rs148314165, rs200820567) located in the genomic DNA 30 kb telomeric of TNFAIP3 to be the most likely candidate variants responsible for association with SLE based on transpopulation differences in LD between in associated (European and Asian) and non-associated (African American) populations and bioinformatic annotation demonstrating that these variants are located in an evolutionarily conserved region of regulatory significance [27]. Here, TNFAIP3 is linked to systemic lupus erythematosus.