Lymphoid malignancies such as diffuse large B-cell lymphoma, marginal zone lymphoma, follicular lymphoma, MALT lymphoma and Hodgkin lymphoma, often carry deletions or inactivating point mutations in TNFAIP3 suggesting a role for TNFAIP3 as a tumor suppressor [19]–[23]. The gene discussed is TNFAIP3; the disease is diffuse large B-cell lymphoma.