As expected, concordance analysis between ER+ and ER− breast cancer DRGEPs and TREG signatures of ERα and E2F1 activity demonstrated involvement of E2F1 regulation in both DRGEPs (p-value = 7.0×10−14 for ER+ and p-value = 1.3×10−72 for ER−). The gene discussed is E2F1; the disease is breast cancer.