CLCN3 and cancer: A more detailed analysis of Clcn3 expression and sub-cellular distribution in the future could be very insightful; similarly, it will be interesting to study whether the role of Clcn3 observed here in the context of cancer pain also extends to the modulation of inflammatory or neuropathic pain states, given especially our observation that knocking down the basal expression of Clcn3 by itself significantly impacted on mechanical sensitivity in the absence of tumour growth.