Whereas control siRNA-treated mice did not develop any hypersensitivity to extremely low magnitude of mechanical force, such as in response to the von Frey filament exerting 0.02 g force until 11 days after tumour-induction, Clcn3-siRNA-treated mice showed significant hypersensitivity to 0.02 g from PID-5 onwards (Fig 6, panel E). The gene discussed is CLCN3; the disease is neoplasm.