Both cancer cell lines demonstrate altered regulation of the NFkB signaling pathway, since there is generally increased expression of the main component of NFkB complexes: RELA (p65), its inhibitors: KBKE, kinase of inhibitors CHUK, and kappa light polypeptide gene enhancer in B-cells 3, p65: NFKBIA and NFKBIB. Here, CHUK is linked to cancer.