In HCC, deregulation of the PI3K/Akt pathway is the result of multiple molecular mechanisms, including activating mutations of PI3K p110α catalytic subunit, loss of expression of its negative regulator, the lipid phosphatase and tensin homolog deleted on chromosome ten (PTEN) or aberrant activation of receptor tyrosine kinases [13]. This evidence concerns the gene PTEN and hepatocellular carcinoma.