ANRIL is located in the INK4b/ARF/INK4a locus, and it is coregulated with INK4a, INK4b and ARF. Expression studies have confirmed that ANRIL is expressed in multiple atherosclerosis-related cell lines, including vascular endothelial cell, monocyte-derived macrophages and coronary smooth muscle cells [64,120]. The gene discussed is CDKN2B; the disease is atherosclerosis.