DYNC1H1 and amyotrophic lateral sclerosis: SOD1G93A transgenic ALS mice were crossed to Dync1h1+/Loa mice and double-mutant progeny (i.e., SOD1G93ADync1h1Loa) surprisingly lived 28% longer than their SOD1G93A transgenic littermates, with a significant increase in survival of spinal cord motor neurons at a 120-day late-disease time point compared with SOD1G93A littermates [43] (Table 4).