We found that azacitidine treatment suppressed the growth of RCC cell lines but the response to azacitidine was not restricted to VHL methylated cell lines, and so to identify novel epigenetically inactivated candidate TSGs for RCC we proceeded to analyse the results of combined copy number and methylation profiling on primary RCC tumours, and investigate whether methylation of such genes was associated with survival. Here, VHL is linked to renal cell carcinoma.