Five genes demonstrated complete loss or downregulation of expression in at least 20% of RCC tumours (GCM2 (80% of RCC), RGS7 (46.7%), TMEM74 (46.7%), NEFM (20%) and AEBP1 (20%)) (Table 1, Figures 4B and 5B-C). This evidence concerns the gene TMEM74 and renal cell carcinoma.