Thus, mutations in genes implicated in chromatin remodelling and modification such as PBRM1, SETD1, KDM6A/UTX and BAP1 have recently been shown to be frequently found in RCC [10-13] and more than 60 candidate TSGs have been reported to demonstrate promotor region methylation in RCC [2] (and references within). This evidence concerns the gene PBRM1 and renal cell carcinoma.