To determine the effect that the perturbation of the RXRα pathway would have on infection, and hence to examine the potential of the expression profiling approach that we have used for the discovery of important host response pathways, we treated mice with HX351 prior to and for 4 days following infection with Td-tomato L. donovani amastigotes (Figure 6A). The gene discussed is RXRA; the disease is infection.