To support this hypothesis, various studies investigated secreted frizzled-related protein 1 (SFRP1) in HCC [38-41], and Kaur P et al. indicated SFRP1 expression was downregulated by methylation resulting in activation of the Wnt pathway and contributing to increased HCC cell growth and proliferation [41]. The gene discussed is FRZB; the disease is hepatocellular carcinoma.