The genetic basis of HUPRA syndrome in Palestinian patients was a homozygous mutation (c.1169A > G p.D390G) in the SARS2 gene (RefSeq NG_031865.1) [10], which encodes mitochondrial seryl‒tRNA synthetase [7]. Here, SARS2 is linked to hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome.