Here, the level of type IV collagen decreases; type IV collagen has an important role in basal membrane remodeling and turnover (17, 19).The M30 fragment of CK-18 has been identified as a useful marker associated with increased severity of fibrosis and inflammation in chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) (20). Here, KRT18 is linked to cryohydrocytosis.