IL17F and asthma: However, although a good case can be made for IL-17A and IL-17F in mouse models of neutrophilic and corticosteroid-refractory lung responses to allergens, evidence for IL-17 involvement in human asthma is less robust, despite some emerging genetic evidence and a potential role for IL-17A and IL-17F in moderate-to-severe disease (Chakir et al., 2003; Doe et al., 2010).