This is because NRF2 is up-regulated in response to front-line chemotherapy agents including cyatarbine/daunorubicin, bortezomib (myeloma) and 5-fluorouracil (colon cancer), resulting in the induction of cytoprotective genes, thereby contributing to the decrease in the cell's sensitivity to these drugs [37-39]. This evidence concerns the gene NFE2L2 and colonic neoplasm.