The comparison analysis yielded three genes that were commonly identified as deregulated both in human patients with severe sepsis and acute respiratory distress syndrome, as well as experimental rodents: the orphan G-protein coupled receptor 182; the dedicator of cytokinesis protein 9, a Cdc42 guanine nucleotide exchange factor; and Aqp1, a 28 KDa water channel protein. The gene discussed is AQP1; the disease is acute respiratory distress syndrome.