Aside from this being one of the first reports of Aqp1 expression in human leukocytes and PMNs, our results document that sepsis and LPS are associated with Aqp1 induction in leukocytes and neutrophils and this could be an important event in neutrophil activation in the setting of sepsis, as well as a biomarker of the latter. The gene discussed is AQP1; the disease is Sepsis.