A study by Pezelj-Ribaric and colleagues in subjects with burning mouth syndrome before and after treatment with LLLT (685 nm continuous wave, 30 mW output power, 3.0 J/cm2) that analyzed the expression of TNFα and IL-6 in saliva showed a statistically significant reduction in salivary levels of both after treatment with LLLT [33]. The gene discussed is IL6; the disease is burning mouth syndrome.