Obesity is considered as an inflammatory status, because proinflammatory molecules, expressed by adipose tissue such as leptin, TNF-α, IL-6, TGF- β1, adiponectin and C-reactive protein, are increased in obese subjects [23,25], especially in females (mainly C-reactive protein and leptin) [20]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.