By univariate Cox-regression analysis the predictors for major cardiovascular events were: age (HR = 1.031), hypertension (HR = 2.38), previous ischemic heart disease (HR = 4.33) hs-CRP (HR = 1.87), TNT (HR = 2.02), albuminuria (HR = 1.87), and IgM-uria (HR = 2.96), Table 2. The gene discussed is CD40LG; the disease is hypertensive disorder.