This is further strengthened by the fact that elevations of hs-CRP, reflecting systemic inflammation associated with atherosclerosis [27], and troponin T, more reflecting cardiac muscle ischemia, were coupled to the presence of CAD [28,29] and to MA and IgM-uria, in turn signaling a poor cardiovascular outcome [12,13]. The gene discussed is CD40LG; the disease is coronary artery disorder.