IL10 and infection: For instance, in the study of Whary et al., in which both Helicobacter free IL-10−/− (B6 background) and B6 mice were infected with H. trogontum, a rapid development of an acute-on-chronic typhlocolitis, epithelial hyperplasia, and dysplasia was observed following infection of Helicobacter free IL-10−/− mice on a B6 background with H. trogontum [10].