Multiple myeloma (MM) is a plasma cell malignancy where plasma cells areincreased in the bone marrow (BM) and usually do not enter peripheral blood, but produceharmful factors creating problems in these patients (e.g. malignant plasma cells over activate osteoclasts and inhibit osteoblasts with factors like RANKL and DKK). Here, TNFSF11 is linked to AL amyloidosis.