Also Gaur et al. have demonstrated thatWnt signaling induces bone formation directly bystimulating Runx2 expression as an essential transcription factor for osteoblast maturation (11, 25).Colucci et al. also studied MM patients and verifiedthat plasma cells of MM patients have significantexpression of SOST (26). The gene discussed is RUNX2; the disease is Miyoshi myopathy.