The same analysis demonstrated that in luminal A and luminal B (ER plus HER2 positive) tumors, pCR is not associated with prognosis, whereas in patients with highly proliferating carcinomas like triple negative breast cancer (TNBC) or HER2 enriched tumors (HER2 positive plus ER negative), pCR can accurately discriminate between good and poor prognosis [15]. This evidence concerns the gene ERBB2 and carcinoma.