In men, UGT2B15(D85Y) and the UGT2B17 deletion were both associated with alterations in serum steroid levels and fat mass (23, 57, 58) and the UGT215(D85Y) variation (56, 59) has been reported to be associated with increased prostate cancer risk in unselected (59), Caucasian (60) and Japanese (61) subjects. The gene discussed is UGT2B17; the disease is Familial prostate cancer.