This emerging crucial role for adrenal GRK2 in HF is underlined by the fact that its specific inhibition, via adenoviral-mediated βARKct adrenal gene delivery, leads to a significant reduction in circulating catecholamine levels, restoring not only adrenal, but also cardiac function in HF (Lymperopoulos et al., 2007). The gene discussed is GRK2; the disease is hydrops fetalis.