HK2 binding to the conduit channeling ATP out of mitochondria provides a metabolic benefit to cancer cells (Warburg effect) and it antagonizes cell death via inhibition of Bax-induced cyt c release (Pastorino et al., 2002; Gall et al., 2011) and/or inhibition of the Mitochondrial Permeability Transition (MPT) (Chiara et al., 2008). Here, BAX is linked to cancer.