Overexpression of HDAC5 reduces PGC-1α in the heart (Czubryt et al., 2003) by blocking the developmental induction of PGC-1α by myocyte enhancing factor 2 (MEF2), and exposure of neuroblastoma cells to the HDAC inhibitors trichostatin A or valproic acid (a mood stabilizer given as adjunct therapy to schizophrenia patients) increases mRNA level of PGC-1α and its target gene glucose transporter four (Cowell et al., 2009). Here, PPARGC1A is linked to schizophrenia.