Studies in reverse-translational models using schizophrenia-risk genes, such as ErbB4 (Fisahn et al., 2009; Neddens and Buonanno, 2010), DISC1 (Hikida et al., 2007; Shen et al., 2008; Ayhan et al., 2011), DTNP1 (Ji et al., 2009; Carlson et al., 2011), BDNF (Sakata et al., 2009) and glutamate cysteine ligase modifier (GCLM; Steullet et al., 2010; Cabungcal et al., 2013a), consistently observed a decreased number or impaired function of PVIs in the hippocampus or cortex. The gene discussed is DISC1; the disease is schizophrenia.