DISC1 and schizophrenia: Furthermore, abnormal proteins encoded by schizophrenia susceptibility genes (PRODH, DISC1, DAOA, NRG1, G72) cause oxidative stress and/or hypersensitivity to oxidative stress (Goldshmit et al., 2001; Krishnan et al., 2008; Drews et al., 2012) or mitochondrial dysfunction (Park et al., 2010).