Combination of CaMK-DN-DISC1 × prenatal polyI:C produced new phenotypes not seen with either variable alone: anxiety, as measured by increased peripheral activity in the open field and by open arm time in the elevated plus maze; depression-like behavior, as measured by increased immobility in the forced swim test; and impaired sociability in the three-chamber social test. The gene discussed is DISC1; the disease is depressive disorder.