Polymorphisms in the glucocorticoid receptor and its regulator FK506 binding protein 5 (FKBP5) as well as in the CRH type I receptor interact with early life stress in predicting depression (Bradley et al., 2008) or in the case of FKBP5, post-traumatic stress disorder (Binder et al., 2008). The gene discussed is FKBP5; the disease is major depressive disorder.