DISC1 and schizophrenia: These models, identified in a screen of ENU-mutagenized mice, express missense mutations in Disc1. The Q31L mutant mice showed depressive-like behavior (deficits in the forced swim test and other measures that were reversed by the antidepressant) whereas L100P mutants exhibited schizophrenia-like behavior (PPI and latent inhibition deficits which were reversed by antipsychotic treatment) (Clapcote et al., 2007).