CEP290 and Joubert syndrome: Although WNT signaling was not investigated in the Cep290 (centrosomal protein 290 kDa) mutants, the data suggest that a WNT signaling defects might also underlie Joubert syndrome caused by mutations in Joubert-associated genes other than AHI1. This study clearly implicates deregulated WNT signaling as a mechanism in Joubert syndrome.