The IL-6 level in gastrocnemius muscle increased in group L compared with group C. The role of IL-6 action in obesity-associated insulin resistance remains highly controversial; Wunderlich et al. [51] showed that mice with a hepatic deficiency of IL-6 receptor a (IL-6Ra) develop insulin resistance not only in the liver but also in skeletal muscle and WAT. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.