As interferon response and RNAi silencing in HIV-1 infection involves downregulation of Dicer [32] and possible upregulation of many Dicer independent microRNAs [54], further research on Ago2 processed endogenous and exo-miRNAs might explain the cross talks these two antiviral pathway play in modulating the HIV-1 replication. Here, DICER1 is linked to HIV-1 infection.