AGO2 and HIV-1 infection: As interferon response and RNAi silencing in HIV-1 infection involves downregulation of Dicer [32] and possible upregulation of many Dicer independent microRNAs [54], further research on Ago2 processed endogenous and exo-miRNAs might explain the cross talks these two antiviral pathway play in modulating the HIV-1 replication.