Furthermore, Fas-L activated through aspirin effectively inhibits the growth and metastasis of MMs in vitro and in vivo. Our results showed the additive or synergistic anti-MM activity of MSCs with highly activated Fas-L, measured on the basis of cell growth, apoptosis, and modest survival improvement of MM-bearing mice, indicating that the levels of Fas-L expression in MSCs determine, at least partially, the effect of MSCs on cancer growth. Here, FASLG is linked to cancer.