There is less evidence implicating the FA core proteins in breast cancer [83] but exome sequencing did uncover truncating mutations of FANCC and of FANCM in single studies [47,49] and rare truncating mutations have also been observed in SLX4 (the FANCP gene) [50,51,84] suggesting that more FA genes might harbour rare breast cancer susceptibility alleles at a very low frequency. Here, SLX4 is linked to breast cancer.