IGHE and asthma: The precise mechanism for this is not clearly understood, but several workers have postulated that multiple genes are involved in pathogenesis of asthma such as; production of allergen-specific Immunoglobulin E(IgE), expression of broncho hyper-responsiveness, generation of inflammatory mediators such as cytokines and chemokines, and modulation of Th2 response to antigens [25-27].