We have previously characterized an IP model of MM in severe combined immunodeficient (SCID) mice [9], and have evaluated the potential of acid-prepared mesoporous silica particles (APMS) for their ability to target and be retained by spheroid and mesenteric MMs in vivo following modification with an antibody specific to human mesothelin (APMS-MB) [10]. Here, MSLN is linked to Miyoshi myopathy.