A mesothelin tumor vaccine (CRS-207) is currently in a phase II trial in combination with the pancreatic cancer vaccine GVAX [36], and a pre-clinical in vitro study has reported the success of a lentivirus-expressing anti-mesothelin microRNA (MSLNmiR3) that silences the mesothelin gene (MSLN). The gene discussed is MSLN; the disease is pancreatic neoplasm.