Our results indicate that in our admixed population the association between disease development and IFNG+874T/A and NOS2A-954G/C SNPs does not exert selective pressure on M. tuberculosis via immune response surveillance, as shown by the absence of correlation of active TB with these SNPs profiles but can lead to different approaches to evaluate the tuberculosis immunopathology genetics background in the near future. Here, IFNG is linked to tuberculosis.