CXCL12 and asthma: On the other side, the defective myelopoiesis and lymphopoiesis in parallel with lack of cardiovascular development in CXCL12 or CXCR4 (its receptor) may prove its role in homeostasis roles rather than inflammatory properties [19, 37, 38]; thus, increased circulatory level of CXCL12 in our asthma patients may be related to its role in remodeling of airways as an homeostatic chemokine rather than its other roles.