Our results showed that the polymorphisms of the NRAMP1 gene (3′UTR) and VDR gene (FokI) are significantly associated with TB and may be risk factors for the development of TB in the Chinese Kazak population (OR = 1.859 and 1.530; P = 0.002 and 0.001, resp). This evidence concerns the gene SLC11A1 and tuberculosis.