Moreover, curcumin mediated inhibition of Notch1 activation also led to the downregulation of NF-κB and its target genes, including Bcl-2, cyclin D1, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-9 (MMP-9) in oral squamous cell carcinoma cells [14]. This evidence concerns the gene NOTCH1 and oral cavity squamous cell carcinoma.