At the age of 12 arthritis relapsed and patient treated with cyclosporine (200 mg/day), methotrexate (15 mg/day) and oral prednisone (0.2 mg/Kg/day followed by gradual tapering of the dosage); starting from the age of 13, she was treated with intravenous infusions of anti-TNF biological agents (Infliximab). The gene discussed is TNF; the disease is arthritic joint disease.