4 weeks after infection, compared with CVB3-treated mice that received Tregs exhibited a significant resolution of cardiac fibrosis demonstrated by picrosirius-red staining and CVF evaluation; In contrast, the protective effect of Tregs was significantly impaired by the blockade of IL-10 (Figure 5A, P < 0.05) indicating IL-10 played an important role in Tregs-mediated protection against cardiac fibrosis. Here, IL10 is linked to infection.