Tumor migration and invasion by TGF-β-induced crosstalk between signaling pathways, including Smad, non-Smad and Wnt signaling pathways, accompany the increased expression and activity of matrix metalloproteinases (MMPs), which have been recognized as major contributors to the proteolytic degradation of the extracellular matrix that is required for tumor cell migration and invasion [19]. This evidence concerns the gene TGFB1 and neoplasm.