The altered expression of EGFR in human GBM is generally correlated with high proliferative behavior and with resistance to apoptosis although its involvement in the acquisition of the migratory phenotype could be inferred by the demonstration that EGFR over-expression confers migratory properties to otherwise non-migrating neural progenitor cells [15] and that EGF can act as a potent motogen for GBM cells [6]. Here, EGF is linked to glioblastoma.