In addition, in another liver cancer cell line HepG2 derived from hepatoblastoma, p53 knockdown together with insulin and TGF-β1 treatment could cause maximal reduction of E-cadherin and ZO-1 expression and stimulation of Snail, Zeb1 and vimentin expression (Figure S2 in File S1). The gene discussed is INS; the disease is hepatoblastoma.