Furthermore, bioinformatics analysis showed that these 88 proteins were significantly enriched in several KEGG pathways, including cell cycle (p = 7.83×10–4 after FDR multiple-test correction), neurotrophin signaling pathway (p = 2.57×10–3), chronic myeloid leukemia (p = 2.57×10–3), and DNA replication (p = 1.16×10–2). This evidence concerns the gene BDNF and chronic myelogenous leukemia, BCR-ABL1 positive.