A statistically significant correlation was established between tumor volume and the levels of plasmatic S100A4 (Fig. 6C), and the analysis by RT-PCR and WB demonstrated the presence of mRNA and S100A4 protein, respectively, only in cells transfected with the mock vector compared with the transfected with shRNA-S100A4 (Fig. S1A and B). The gene discussed is S100A4; the disease is neoplasm.