S100A4 and cancer: Intracellular S100A4 is involved in: i) the motility and the metastatic capacity of cancer cells, interacting with cytoskeletal components such as the heavy chain of non-muscle myosin; ii) cell adhesion and detachment by interaction with cadherins; iii) remodeling of the extracellular matrix (ECM) by interaction with matrix metalloproteinases (MMPs), and iv) cell proliferation through its binding and sequestration of the tumor-suppressor protein p53 [10], [14], [15].