S100A4 secreted by tumor and stromal cell (macrophages, fibroblasts, and activated lymphocytes into the tumor microenvironment) is a key player in promoting metastasis; it alters the metastatic potential of cancer cells, acting as an angiogenic factor inducing cell motility, and increasing the expression of MMPs [9], [16], [17]. Here, S100A4 is linked to neoplasm.