Our analysis highlighted one factor (IGF1R) that is found upregulated in p53 negative cells in the model and at least two different cancer cell lines, and in addition indicated that different cell lines may have additional growth factor combinations and dependencies, as colon cancer cells not exposed to DNA damage had upregulated PDGFR whereas SAOS2 cell did not, when compared to their p53 positive counterparts. This evidence concerns the gene TP53 and malignant colon neoplasm.