Six weeks after diabetes was induced in untreated and insulin-treated STZ-induced diabetic rats, TFL to thermal stimuli (Fig. 1a) was increased (thermal hypoalgesia) by 23% (p<0.05) and 18% (p<0.05), respectively, whereas MNT to pressure stimuli (Fig. 1b) was decreased (mechanical hyperalgesia) by 10% (not significant; p > 0.05) and 16% (marginally significant; p = 0.05), respectively, compared with control rats. This evidence concerns the gene INS and diabetes mellitus.