TG and hyperthyroidism: [14] Moreover, some studies revealed that the onset of bipolar disorder is not associated with gender. [15] However, women with hyperthyroidism were at greater risk of developing bipolar disorders than the men in our study. It is possible that mechanisms associated with thyroid hormones and estrogens may have overlapping functions. [16] Studies has shown that women who are vulnerable to fluctuating estrogen levels may be at increased risk for developing bipolar disorders [17].